Rb1^{tm1.1(PPP1R26P1)Last}
Targeted Allele Detail

Summary

• Symbol: Rb1^{tm1.1(PPP1R26P1)Last}
• Name: RB transcriptional corepressor 1; targeted mutation 1.1, Laura Steenpass
• MGI ID: MGI:5919937
• Gene: Rb1 Location: Chr14:73430298-73563446 bp, - strand Genetic Position: Chr14, 38.73 cM, cytoband D3
• Alliance: Rb1^{tm1.1(PPP1R26P1)Last} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207568
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A loxP site flanked neomycin resistance gene cassette and the 5.2 kb human pseudogene were inserted into intron 2. The neo cassette was removed through subsequent cre-mediated recombination. The pseudogene contains a CpG island that is differentially (maternally) methylated and has promoter function in human. Mice derived from ES cell clone 42 were used for further breeding. (J:207568)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rb1 Mutation: 116 strains or lines available

References

• Original: J:207568 Steenpass L, et al., Human PPP1R26P1 functions as cis-repressive element in mouse Rb1. PLoS One. 2013;8(9):e74159
• All: 2 reference(s)