E2f1^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: E2f1^tm1.1Arte
• Name: E2F transcription factor 1; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:5912501
• Synonyms: E2f1^tm3110Arte
• Gene: E2f1 Location: Chr2:154401327-154411812 bp, - strand Genetic Position: Chr2, 76.79 cM
• Alliance: E2f1^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229821
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and FRT-flanked puro resistance cassette were inserted in intron 1 and a loxP site was inserted in intron 3 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:229821)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any E2f1 Mutation: 28 strains or lines available

References

• Original: J:229821 Denechaud PD, et al., E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis. J Clin Invest. 2016 Jan 4;126(1):137-50
• All: 2 reference(s)