Paxip1^tm1.1Jada
Targeted Allele Detail

Summary

• Symbol: Paxip1^tm1.1Jada
• Name: PAX interacting (with transcription-activation domain) protein 1; targeted mutation 1, Jeremy A Daniel
• MGI ID: MGI:5911870
• Synonyms: PTIP^gfp
• Gene: Paxip1 Location: Chr5:27945078-27996689 bp, - strand Genetic Position: Chr5, 13.23 cM, cytoband A3
• Alliance: Paxip1^tm1.1Jada page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229465
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (No functional change, Reporter)
• Mutation: Insertion
• Mutation details: A GFP gene was fused in frame to the C terminus of the gene and a self-excising floxed pgk-neo cre cassette was inserted downstream of the GFP gene. Cre mediate recombination removed the cassette. GFP tagged protein is detected in primary cells by Western blotting and flow cytometry. (J:229465)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Paxip1 Mutation: 49 strains or lines available

References

• Original: J:229465 Starnes LM, et al., A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Genes Dev. 2016 Jan 15;30(2):149-63
• All: 2 reference(s)