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Nus1tm1.1Qrm
Targeted Allele Detail
Nomenclature
Symbol: Nus1tm1.1Qrm
Name: NUS1 dehydrodolichyl diphosphate synthase subunit; targeted mutation 1.1, Qing Robert Miao
MGI ID: MGI:5911854
Gene: Nus1  Location: Chr10:52417547-52440192 bp, + strand  Genetic Position: Chr10, 26.64 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:243753
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2 and a loxP site and FRT-flanked neo cassette were inserted downstream of exon 4 via homologous recombination. Flp-mediated recombination removed the neo cassette. (J:243753)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nus1 Mutation:  10 strains or lines available
References
Original:  J:243753 Hu W, et al., Nogo-B receptor deficiency increases liver X receptor alpha nuclear translocation and hepatic lipogenesis through an adenosine monophosphate-activated protein kinase alpha-dependent pathway. Hepatology. 2016 Nov;64(5):1559-1576
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/18/2018
MGI 6.12
The Jackson Laboratory