Smo^cbb
Chemically induced Allele Detail

Summary

• Symbol: Smo^cbb
• Name: smoothened, frizzled class receptor; cabbie
• MGI ID: MGI:5911831
• Synonyms: Smo^m1Tc
• Gene: Smo Location: Chr6:29735502-29761364 bp, + strand Genetic Position: Chr6, 12.36 cM, cytoband A3.3
• Alliance: Smo^cbb page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a C-to-A change in exon 3 resulting in asparagine to lysine change at amino acid position 223 (p.N223K). (J:262122)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:

26 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smo Mutation: 39 strains or lines available

References

• Original: J:262122 Gigante ED, et al., Hypomorphic Smo mutant with inefficient ciliary enrichment disrupts the highest level of vertebrate Hedgehog response. Dev Biol. 2018 May 15;437(2):152-162
• All: 1 reference(s)