Ddx4tm1.2Embrp
Targeted Allele Detail
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Symbol: |
Ddx4tm1.2Embrp |
Name: |
DEAD box helicase 4; targeted mutation 1.2, Ramesh Pillai |
MGI ID: |
MGI:5911766 |
Synonyms: |
MvhE446Q, MvhKI |
Gene: |
Ddx4 Location: Chr13:112734867-112789009 bp, - strand Genetic Position: Chr13, 63.87 cM
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Alliance: |
Ddx4tm1.2Embrp page
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: LoxP sites were inserted into intron 15 and 16 and glutamic acid codon 446 (GAA) in exon 16 was changed to glutamine (CAA) (p.E446Q). This mutation is expected to disrupt the protein activity. The kanamycin-neomycin resistance gene cassette that was inserted into intron 15 was removed through subsequent Flp-mediated recombination. Cre-mediated recombination removed modified exon 16.
(J:243488)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ddx4 Mutation: |
58 strains or lines available
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Original: |
J:243488 Wenda JM, et al., Distinct Roles of RNA Helicases MVH and TDRD9 in PIWI Slicing-Triggered Mammalian piRNA Biogenesis and Function. Dev Cell. 2017 Jun 19;41(6):623-637.e9 |
All: |
1 reference(s) |
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