Tdrd9^tm1.2Embrp
Targeted Allele Detail

Summary

• Symbol: Tdrd9^tm1.2Embrp
• Name: tudor domain containing 9; targeted mutation 1.2, Ramesh S Pillai
• MGI ID: MGI:5911765
• Gene: Tdrd9 Location: Chr12:111937993-112035288 bp, + strand Genetic Position: Chr12, 61.14 cM, cytoband F2
• Alliance: Tdrd9^tm1.2Embrp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243488
• Parent Cell Line: A9 (ES Cell)
• Strain of Origin: (C57BL/6 x 129P2/OlaHsd)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted into introns 2 and 5 and glutamic acid codon 257 (GAG) in exon 5 was changed to glutamine (CAG) (p.E257Q). The FRT site flanked kanamycin-neomycin resistance gene cassette that was inserted into intron 5 was removed through subsequent Flp-mediated recombination. Cre-mediated recombination removed exons 3 through 5. (J:243488)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tdrd9 Mutation: 73 strains or lines available

References

• Original: J:243488 Wenda JM, et al., Distinct Roles of RNA Helicases MVH and TDRD9 in PIWI Slicing-Triggered Mammalian piRNA Biogenesis and Function. Dev Cell. 2017 Jun 19;41(6):623-637.e9
• All: 1 reference(s)