Cd226^tm1.1Vei
Targeted Allele Detail

Summary

• Symbol: Cd226^tm1.1Vei
• Name: CD226 antigen; targeted mutation 1.1, Andre Veillette
• MGI ID: MGI:5911669
• Synonyms: Cd226^Y319F
• Gene: Cd226 Location: Chr18:89195091-89290353 bp, + strand Genetic Position: Chr18, 59.05 cM
• Alliance: Cd226^tm1.1Vei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229022
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Single point mutation
• Mutation details: An FRT flanked pgk-neo cassette was inserted in intron 6 and an A to T mutation was inserted in exon 7 creating a Y319F mutation via homologous recombination. Flp mediated recombination removed the neo cassette. The mutation prevents phosphorylation at this site. (J:229022)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd226 Mutation: 32 strains or lines available

References

• Original: J:229022 Zhang Z, et al., DNAM-1 controls NK cell activation via an ITT-like motif. J Exp Med. 2015 Nov 16;212(12):2165-82
• All: 2 reference(s)