Prkag2^tm1.1Rti
Targeted Allele Detail

Summary

• Symbol: Prkag2^tm1.1Rti
• Name: protein kinase, AMP-activated, gamma 2 non-catalytic subunit; targeted mutation 1.1, Rong Tian
• MGI ID: MGI:5911532
• Synonyms: gamma2-AMPK cKO
• Gene: Prkag2 Location: Chr5:25067742-25305640 bp, - strand Genetic Position: Chr5, 11.93 cM
• Alliance: Prkag2^tm1.1Rti page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:341591
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site followed by an FRT-flanked neomycin resistance (neo) cassette, upstream of exon 6, and a second loxP site was inserted downstream of exon 6 of the gene. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 6 floxed. (J:341591)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkag2 Mutation: 53 strains or lines available

References

• Original: J:341591 Cao Y, et al., Activation of gamma2-AMPK Suppresses Ribosome Biogenesis and Protects Against Myocardial Ischemia/Reperfusion Injury. Circ Res. 2017 Oct 27;121(10):1182-1191
• All: 1 reference(s)