Tet2^tm2.1Mjxu
Targeted Allele Detail

Summary

• Symbol: Tet2^tm2.1Mjxu
• Name: tet methylcytosine dioxygenase 2; targeted mutation 2.1, Mingjiang Xu
• MGI ID: MGI:5911445
• Synonyms: Tet2:flox
• Gene: Tet2 Location: Chr3:133169438-133250882 bp, - strand Genetic Position: Chr3, 61.84 cM
• Alliance: Tet2^tm2.1Mjxu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228945
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 11 and a loxP site and FRT flanked neo cassette were inserted in intron 12 via homologous recombination. Flp-mediated recombination removed the neo cassette leaving exon 11 floxed. (J:228945)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tet2 Mutation: 783 strains or lines available

References

• Original: J:228945 Zhao Z, et al., Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice. Cell Rep. 2015 Nov 24;13(8):1692-704
• All: 4 reference(s)