Scd2^tm1.1Ntam
Targeted Allele Detail

Summary

• Symbol: Scd2^tm1.1Ntam
• Name: stearoyl-Coenzyme A desaturase 2; targeted mutation 1.1, James M Ntambi
• MGI ID: MGI:5911062
• Synonyms: Scd2 cKO, Scd2^lox, Scd2^tm2.1Myz
• Gene: Scd2 Location: Chr19:44282115-44295303 bp, + strand Genetic Position: Chr19, 37.98 cM
• Alliance: Scd2^tm1.1Ntam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229399
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted surrounding exon 3, which encodes the catalyic domain of the encoded protein. An frt-flanked neomycin selection cassette 3' to exon 3 was removed via FLP-mediated recombination in the final allele. (J:229399)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scd2 Mutation: 30 strains or lines available

References

• Original: J:229399 Masuda M, et al., Saturated phosphatidic acids mediate saturated fatty acid-induced vascular calcification and lipotoxicity. J Clin Invest. 2015 Dec;125(12):4544-58
• All: 3 reference(s)