Ptk2b^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Ptk2b^tm1.1Geno
• Name: PTK2 protein tyrosine kinase 2 beta; targeted mutation 1.1, Genoway
• MGI ID: MGI:5911061
• Synonyms: Pyk2^-
• Gene: Ptk2b Location: Chr14:66390706-66518501 bp, - strand Genetic Position: Chr14, 34.36 cM
• Alliance: Ptk2b^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229315
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: LoxP sites were inserted to flank exons 15-18 and an frt-flanked neomycin selection cassette. Cre-mediated recombination in the germ line resulted in a deletion of the genomic region containing exons 15-18. These exons encode the kinase domain. Western blot and immunohistochemistry studies showed that no detectable encoded protein is expressed from this allele. (J:229315)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptk2b Mutation: 57 strains or lines available

References

• Original: J:229315 Giralt A, et al., Pyk2 is essential for astrocytes mobility following brain lesion. Glia. 2016 Apr;64(4):620-34
• All: 5 reference(s)