Meis2^tm1.2Hko
Targeted Allele Detail

Summary

• Symbol: Meis2^tm1.2Hko
• Name: Meis homeobox 2; targeted mutation 1.2, Haruhiko Koseki
• MGI ID: MGI:5910982
• Synonyms: Meis2^KO
• Gene: Meis2 Location: Chr2:115693545-115896320 bp, - strand Genetic Position: Chr2, 58.28 cM
• Alliance: Meis2^tm1.2Hko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229011
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site and an frt-flnaked neomycin selection cassette was inserted upstream of exon 8, and a single loxP site was inserted downstream of exon 8. FLP and Cre-mediated recombination resulted in the removal of the selection cassette and exon 8 in the final allele. (J:229011)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Meis2 Mutation: 30 strains or lines available

References

• Original: J:229011 Yakushiji-Kaminatsui N, et al., RING1 proteins contribute to early proximal-distal specification of the forelimb bud by restricting Meis2 expression. Development. 2016 Jan 15;143(2):276-85
• All: 1 reference(s)