Ppargc1b^tm1.1Mtz
Targeted Allele Detail

Summary

• Symbol: Ppargc1b^tm1.1Mtz
• Name: peroxisome proliferative activated receptor, gamma, coactivator 1 beta; targeted mutation 1.1, Daniel Metzger
• MGI ID: MGI:5910594
• Synonyms: PGC-1b^L2
• Gene: Ppargc1b Location: Chr18:61431207-61533502 bp, - strand Genetic Position: Chr18, 34.41 cM
• Alliance: Ppargc1b^tm1.1Mtz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228281
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 5. Flp-mediated recombination removed the neo cassette leaving exon 5 floxed. (J:228281)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppargc1b Mutation: 59 strains or lines available

References

• Original: J:228281 Gali Ramamoorthy T, et al., The transcriptional coregulator PGC-1beta controls mitochondrial function and anti-oxidant defence in skeletal muscles. Nat Commun. 2015;6:10210
• All: 1 reference(s)