Col4a1^tm1Dbg
Targeted Allele Detail

Summary

• Symbol: Col4a1^tm1Dbg
• Name: collagen, type IV, alpha 1; targeted mutation 1, Douglas B Gould
• MGI ID: MGI:5910508
• Synonyms: Col4a1^Flex41, Col4a1^Flex41-neo
• Gene: Col4a1 Location: Chr8:11248423-11362826 bp, - strand Genetic Position: Chr8, 5.53 cM
• Alliance: Col4a1^tm1Dbg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:234321
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 40 and a second loxP site and an FRT site flanked neomycin resistance gene cassette was inserted into intron 41. This creates a conditional-ready allele with exon 41 floxed (exon numbering as in transcript model CCDS40219.1). (J:234321, J:243720)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Col4a1 Mutation: 76 strains or lines available

References

• Original: J:234321 Jeanne M, et al., Molecular and Genetic Analyses of Collagen Type IV Mutant Mouse Models of Spontaneous Intracerebral Hemorrhage Identify Mechanisms for Stroke Prevention. Circulation. 2015 May 5;131(18):1555-65
• All: 4 reference(s)