Hprt1^{tm1(Cyp1a1-Prl)Mki}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(Cyp1a1-Prl)Mki}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Masao Kakoki
• MGI ID: MGI:5910469
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(Cyp1a1-Prl)Mki} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238788
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inducible, Inserted expressed sequence)
• Inducer: not specified
• Mutation: Insertion
• Hprt1^{tm1(Cyp1a1-Prl)Mki} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prl (MGI:97762)

• Mutation details: The transgene containing a single copy of the inducible rat promoter driving liver-specific expression of the mouse gene with a bovin growth hormone 3'UTR in place of its natural 3'UTR was inserted upstream of exon 1 via homologous recombination. (J:238788)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1280 strains or lines available

References

• Original: J:238788 Chang AS, et al., Prolactin alters blood pressure by modulating the activity of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 2016 Nov 01;113(44):12538-12543
• All: 1 reference(s)