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Targeted Allele Detail
Symbol: Nlrp9btm1c(KOMP)Wtsi
Name: NLR family, pyrin domain containing 9B; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:5910443
Synonyms: Nlrp9b-floxed
Gene: Nlrp9b  Location: Chr7:19991393-20062942 bp, + strand  Genetic Position: Chr7, 9.96 cM
Germline Transmission:  Earliest citation of germline transmission: J:243487
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 20022681 of Chromosome 7 in intron 1 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted in intron 2 at position 20024947. Exon 2 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). (J:243487)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nlrp9b Mutation:  26 strains or lines available
Original:  J:243487 Zhu S, et al., Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. 2017 Jun 29;546(7660):667-670
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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