Disc1^tm1Asaw
Targeted Allele Detail

Summary

• Symbol: Disc1^tm1Asaw
• Name: disrupted in schizophrenia 1; targeted mutation 1, Akira Sawa
• MGI ID: MGI:5910355
• Synonyms: Disc1-LI
• Gene: Disc1 Location: Chr8:125780934-125988597 bp, + strand Genetic Position: Chr8, 73.26 cM
• Alliance: Disc1^tm1Asaw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228295
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv or C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 40kb region encompassing exons 1, 1b, 2 and 3 as well as a miRNA in intron 1 was replaced with a neo cassette via homologous recombination. This deletion also depletes Tsnax - Disc1 intergenic splicing. (J:228295)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Disc1 Mutation: 68 strains or lines available

References

• Original: J:228295 Seshadri S, et al., Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory-inhibitory synapse formation in the mature cortex. Nat Commun. 2015;6:10118
• All: 6 reference(s)