Elmo1^tm1.1Mki
Targeted Allele Detail

Summary

• Symbol: Elmo1^tm1.1Mki
• Name: engulfment and cell motility 1; targeted mutation 1.1, Masao Kakoki
• MGI ID: MGI:5910339
• Synonyms: Elmo1^H
• Gene: Elmo1 Location: Chr13:20274766-20792523 bp, + strand Genetic Position: Chr13, 7.21 cM, cytoband A3.1
• Alliance: Elmo1^tm1.1Mki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230491
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 3'UTR was replaced with A loxP site, unstable mouse Fos 3'UTR, neomycin resistance cassette, loxP site and stable bovine GH 3'UTR. Cre-mediated recombination removed the Fos 3'UTR and selection cassette. QRT-PCR confirmed increased transcript expression in the kidney of 40 week old mice. (J:230491)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elmo1 Mutation: 60 strains or lines available

References

• Original: J:230491 Hathaway CK, et al., High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2218-22
• All: 4 reference(s)