Dnase1l1^tm1Coy
Targeted Allele Detail

Summary

• Symbol: Dnase1l1^tm1Coy
• Name: deoxyribonuclease 1-like 1; targeted mutation 1, Johannes Coy
• MGI ID: MGI:5910227
• Synonyms: DNase X^(-/-), DNase X KO
• Gene: Dnase1l1 Location: ChrX:73316823-73325939 bp, - strand Genetic Position: ChrX, 37.94 cM
• Alliance: Dnase1l1^tm1Coy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243709
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette has replaced exons 2-4 of the gene. Absence of Dnase1l1 mRNA in muscle of homozygous mutant mice was demonstrated by RT-PCR analysis. (J:243709)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dnase1l1 Mutation: 64 strains or lines available

References

• Original: J:243709 Rashedi I, The role of DNase X in skeletal muscle addressed by targeted disruption of the gene in a mouse model. Master's Thesis - University of Manitoba. 2008
• All: 2 reference(s)