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Tg(Myh6-Tnni3*R146G)133Rbns
Transgene Detail
Nomenclature
Symbol: Tg(Myh6-Tnni3*R146G)133Rbns
Name: transgene insertion 133, Jeffrey Robbins
MGI ID: MGI:5909327
Synonyms: TnI146Gly
Transgene: Tg(Myh6-Tnni3*R146G)133Rbns  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-Tnni3*R146G)133Rbns expresses 1 gene
 
Mutation detailsThe murine alpha-myosin heavy chain promoter drives the expression of the mouse troponin I with an arginine to glycine substitution at residue 146 (R146G) in the inhibitory domain which corresponds to the R145G mutation in familial hypertrophic cardiomyopathy in humans. Four lines were generated and two, lines 121 and 133, were analyzed. RNA overexpression levels for line 133 is 3.5-fold higher compared to endogenous RNA. (J:243628)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:243628 James J, et al., Transgenic modeling of a cardiac troponin I mutation linked to familial hypertrophic cardiomyopathy. Circ Res. 2000 Oct 27;87(9):805-11
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory