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Tg(Myh7-Ptpn11*Q510E)#Krnz
Transgene Detail
Nomenclature
Symbol: Tg(Myh7-Ptpn11*Q510E)#Krnz
Name: transgene insertion, Maike Krenz
MGI ID: MGI:5909085
Transgene: Tg(Myh7-Ptpn11*Q510E)#Krnz  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Dominant negative, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh7-Ptpn11*Q510E)#Krnz expresses 1 gene
 
Mutation detailsThe murine beta-myosin heavy chain promoter drives the expression of a Ptpn11 cDNA which contains the amino acid substitution of glutamate for glutamine at position 510 (Q510E). Q510E is a dominant-negative loss-of-function mutation. The beta-myosin heavy chain promoter drives transgene expression starting around E11 and the transgene is expressed stably and continuously after birth. Several lines were generated including: 1, 3, 5, and 6, however, the pound symbol (#) is used when line is not specified and/or lines are pooled. (J:181656)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:181656 Schramm C, et al., The PTPN11 loss-of-function mutation Q510E-Shp2 causes hypertrophic cardiomyopathy by dysregulating mTOR signaling. Am J Physiol Heart Circ Physiol. 2012 Jan;302(1):H231-43
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/10/2019
MGI 6.14
The Jackson Laboratory