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Pcbp2tm1.2Salr
Targeted Allele Detail
Nomenclature
Symbol: Pcbp2tm1.2Salr
Name: poly(rC) binding protein 2; targeted mutation 1.2, Stephen A Liebhaber
MGI ID: MGI:5908914
Gene: Pcbp2  Location: Chr15:102470539-102500061 bp, + strand  Genetic Position: Chr15, 57.61 cM, cytoband F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:235912
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of the transcription initiation site. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 1 and 2. Western blot analysis confirmed the absence of protein expression in embryos. (J:235912)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pcbp2 Mutation:  33 strains or lines available
References
Original:  J:235912 Ghanem LR, et al., The Poly(C) Binding Protein Pcbp2 and Its Retrotransposed Derivative Pcbp1 Are Independently Essential to Mouse Development. Mol Cell Biol. 2015 Nov 02;36(2):304-19
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory