Rela^tm1.1Barts
Targeted Allele Detail

Summary

• Symbol: Rela^tm1.1Barts
• Name: Rela proto-oncogene, NFKB subunit; targeted mutation 1.1, Bart van de sluis
• MGI ID: MGI:5908883
• Synonyms: p65^S467A
• Gene: Rela Location: Chr19:5687511-5698158 bp, + strand Genetic Position: Chr19, 4.34 cM, cytoband B1-3
• Alliance: Rela^tm1.1Barts page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251115
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Single point mutation
• Mutation details: The targeting vector is designed to insert a loxP-flanked neomycin (neo) resistance cassette downstream of exon 10 of the gene. A T to G transition was introduced in exon 11, corresponding to human amino acid 468, resulting in a mutation, S467A. Cre-mediated recombination removed the upstream floxed neo cassette. (J:251115)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rela Mutation: 28 strains or lines available

References

• Original: J:251115 Riedlinger T, et al., NF-kappaB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFalpha-or diet-induced inflammation. Biochim Biophys Acta. 2017 Oct;1864(10):1785-1798
• All: 1 reference(s)