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Tg(tetO/Prnp-MAPT*K280)530Tli
Transgene Detail
Nomenclature
Symbol: Tg(tetO/Prnp-MAPT*K280)530Tli
Name: transgene insertion 530, Tong Li
MGI ID: MGI:5908855
Synonyms: Tau4RdeltaK
Transgene: Tg(tetO/Prnp-MAPT*K280)530Tli  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(tetO/Prnp-MAPT*K280)530Tli expresses 1 gene
 
Mutation detailsThe transgenic construct contains sequence encoding a mutant deltaK280 four-repeat domain of human MAPT protein (Q244-E372) under the control of the mouse Prnp gene promoter and the tetO, tetracycline-responsive regulatory element (from the moPrP-tetP vector; 42-bp tet operator sequence copies followed by the constitutively active, minimal human cytomegalovirus promoter). Frontotemporal dementia and parkinsonism is linked to human chromosome 17 Lysine 280 deletion (deltaK280 or K280del). The Lys280 deletion accelerates aggregation of MAPT (Tau). (J:240784)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:240784 Li T, et al., The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model. Nat Commun. 2016 Jul 04;7:12082
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory