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Tg(Myh6-Mybpc3*)32Rbns
Transgene Detail
Nomenclature
Symbol: Tg(Myh6-Mybpc3*)32Rbns
Name: transgene insertion 32, Jeffrey Robbins
MGI ID: MGI:5908459
Synonyms: MyBP-C.mut1
Transgene: Tg(Myh6-Mybpc3*)32Rbns  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-Mybpc3*)32Rbns expresses 1 gene
 
Mutation detailsThe mouse cardiac truncated protein lacking both the myosin and titin protein binding domains is under the control of the mouse alpha-myosin heavy chain promoter. Western blot analysis confirmed expression of the truncated protein. The truncated protein shows aberrant incorporation into sarcomeres. Five lines were generated: 21, 33, 31, 32, and 15. This is one of the high expressing lines, showing over 6-fold expression levels. (J:50237)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:50237 Yang Q, et al., A mouse model of myosin binding protein C human familial hypertrophic cardiomyopathy. J Clin Invest. 1998 Oct 1;102(7):1292-300
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory