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Postntm2.1(cre/Esr1*)Jmol
Targeted Allele Detail
Summary
Symbol: Postntm2.1(cre/Esr1*)Jmol
Name: periostin, osteoblast specific factor; targeted mutation 2.1, Jeffery Molkentin
MGI ID: MGI:5908450
Synonyms: PostnMCM, Postn-MerCreMer
Gene: Postn  Location: Chr3:54268530-54298458 bp, + strand  Genetic Position: Chr3, 25.46 cM
Alliance: Postntm2.1(cre/Esr1*)Jmol page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:241168
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Inducible, Null/knockout, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Postntm2.1(cre/Esr1*)Jmol expression driven by 1 gene
 
Mutation detailsTamoxifen-inducible cre recombinase (MerCreMer: cre recombinase fused to two modified estrogen receptor ligand binding domains at both ends) cDNA was introduced, in-frame, to the ATG start site of exon 1 via homologous recombination. The plasmid also contains a diptheria toxi A cDNA and a FRT-flanked neomycin cassette for negative and positive selection. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:241168)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Postn (mouse)
Summary of all recombinase alleles driven by Postn.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Postn Mutation:  52 strains or lines available
References
Original:  J:241168 Kanisicak O, et al., Genetic lineage tracing defines myofibroblast origin and function in the injured heart. Nat Commun. 2016 Jul 22;7:12260
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory