Tnfaip3^tm2.1Vmd
Targeted Allele Detail

Summary

• Symbol: Tnfaip3^tm2.1Vmd
• Name: tumor necrosis factor, alpha-induced protein 3; targeted mutation 2.1, Vishva M Dixit
• MGI ID: MGI:5908199
• Synonyms: C609A/C612A, Tnfaip3^z4Cys
• Gene: Tnfaip3 Location: Chr10:18876658-18891158 bp, - strand Genetic Position: Chr10, 8.08 cM
• Alliance: Tnfaip3^tm2.1Vmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228302
• Parent Cell Line: C2 (Nagy) (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: Cysteine to alanine mutations were inserted at position 609 and 612 (C609A and C612A; TGCACTCTATGT to GCTACTCTAGCT) in exon 7 and a floxed neo cassette was inserted at position chr10:18726067 (NCBI37/mm9) via homologous recombination. Cre mediated recombination removed the neo cassette. The mutations disrupt the structure of the ZnF4 ubiquitin binding motif. (J:228302)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfaip3 Mutation: 44 strains or lines available

References

• Original: J:228302 Wertz IE, et al., Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature. 2015 Dec 17;528(7582):370-5
• All: 1 reference(s)