Ptbp1^{tm1c(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Ptbp1^{tm1c(KOMP)Wtsi}
• Name: polypyrimidine tract binding protein 1; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:5908195
• Synonyms: hnRNPI^flox
• Gene: Ptbp1 Location: Chr10:79690502-79700269 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Ptbp1^{tm1c(KOMP)Wtsi} page
• IMPC: Ptbp1 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241364
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 79694165 of Chromosome 10 upstream of exon 3 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 8 at position 79696165. The lacZ and neo cassettes were removed through flp-mediated recombination, leaving a conditional-ready allele with exons 3-8 floxed. (J:241364)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptbp1 Mutation: 36 strains or lines available

References

• Original: J:241364 Jin Z, et al., hnRNP I regulates neonatal immune adaptation and prevents colitis and colorectal cancer. PLoS Genet. 2017 Mar;13(3):e1006672
• All: 3 reference(s)