Arrdc3^tm1.1Rlee
Targeted Allele Detail

Summary

• Symbol: Arrdc3^tm1.1Rlee
• Name: arrestin domain containing 3; targeted mutation 1.1, Richard T Lee
• MGI ID: MGI:5908161
• Synonyms: Arrdc3fl
• Gene: Arrdc3 Location: Chr13:81031508-81044161 bp, + strand Genetic Position: Chr13, 41.95 cM
• Alliance: Arrdc3^tm1.1Rlee page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241367
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_Pgk_P targeting vector from KOMP cell line PRPGS00100_B_H08 was used to create this allele. This vector inserted the following at position 81036838 of Chromosome 13 upstream of exon 3 (Build GRCm39). An FRT site followed by lacZ sequence and a loxP site, a neomycin resistance gene under the control of the PGK promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site was inserted downstream of exon 3. The lacZ and neo cassettes were removed through flp-mediated recombination, leaving a conditional-ready allele with exon 3 floxed. (J:241367)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arrdc3 Mutation: 37 strains or lines available

References

• Original: J:241367 Carroll SH, et al., Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in beta-adrenergic receptor signaling. PLoS One. 2017;12(3):e0173823
• All: 2 reference(s)