Cdk2^tm2.1Kald
Targeted Allele Detail

Summary

• Symbol: Cdk2^tm2.1Kald
• Name: cyclin dependent kinase 2; targeted mutation 2.1, Philipp Kaldis
• MGI ID: MGI:5907858
• Synonyms: Cdk2^fl
• Gene: Cdk2 Location: Chr10:128533808-128540900 bp, - strand Genetic Position: Chr10, 77.13 cM, cytoband D3
• Alliance: Cdk2^tm2.1Kald page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243185
• Parent Cell Line: S1B6 (ES Cell)
• Strain of Origin: 129S1/SvImJ or C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT and loxP site flanked neomycin resistance gene cassette was inserted into intron 5 and a loxP site into intron 3. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exons 4 and 5 floxed. (J:243185)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk2 Mutation: 16 strains or lines available

References

• Original: J:243185 Jayapal SR, et al., Hematopoiesis specific loss of Cdk2 and Cdk4 results in increased erythrocyte size and delayed platelet recovery following stress. Haematologica. 2015 Apr;100(4):431-8
• All: 8 reference(s)