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Tg(HBx-HCV)C5Tto
Transgene Detail
Nomenclature
Symbol: Tg(HBx-HCV)C5Tto
Name: transgene insertion C5, Takeshi Tokuhisa
MGI ID: MGI:5907641
Synonyms: Px-core
Transgene: Tg(HBx-HCV)C5Tto  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe hepatitis B virus X gene (Px) promoter drives the expression of the hepatitis C virus-core cDNA (HCV-1b strain). Northern blot and Western blot analysis confirmed mRNA and protein expression in livers and various tissues including thymus, spleen, brain, heart, lung, kidney intestine, and testis. Two lines, C5 and C8 were established Line C5 is the high expressing line. (J:243110)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:243110 Honda A, et al., HCV-core protein accelerates recovery from the insensitivity of liver cells to Fas-mediated apoptosis induced by an injection of anti-Fas antibody in mice. J Hepatol. 2000 Sep;33(3):440-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory