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Tg(Myh6-LPL*)357Ijg
Transgene Detail
Nomenclature
Symbol: Tg(Myh6-LPL*)357Ijg
Name: transgene insertion 357, Ira J Goldberg
MGI ID: MGI:5907463
Transgene: Tg(Myh6-LPL*)357Ijg  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-LPL*)357Ijg expresses 1 gene
 
Mutation detailsThe human gene ligated to a glycosylphosphatidylinositol (GPI) anchor is under the control of the alpha myosin heavy chain promoter. The GPI anchors the LPL to the cardiomyocyte surface. Northern blot analysis confirmed high expression of the transgene only in the heart. Hearts, but not post-heparin plasma, contains human lipoprotein lipase activity. Three lines were generated; 346, 357, and 358. (J:134550)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:134550 Yagyu H, et al., Lipoprotein lipase (LpL) on the surface of cardiomyocytes increases lipid uptake and produces a cardiomyopathy. J Clin Invest. 2003 Feb;111(3):419-26
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory