Ripk1^tm1.1Mpa
Targeted Allele Detail

Summary

• Symbol: Ripk1^tm1.1Mpa
• Name: receptor (TNFRSF)-interacting serine-threonine kinase 1; targeted mutation 1.1, Manolis Pasparakis
• MGI ID: MGI:5907328
• Synonyms: Ripk1^fl
• Gene: Ripk1 Location: Chr13:34186346-34221130 bp, + strand Genetic Position: Chr13, 14.01 cM
• Alliance: Ripk1^tm1.1Mpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217312
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 2 and a loxP site and FRT flanked neo cassette were inserted in intron 3 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 3 floxed. (J:217312)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ripk1 Mutation: 32 strains or lines available

References

• Original: J:217312 Dannappel M, et al., RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature. 2014 Sep 4;513(7516):90-4
• All: 11 reference(s)