Trem1^tm1.1Cmuel
Targeted Allele Detail

Summary

• Symbol: Trem1^tm1.1Cmuel
• Name: triggering receptor expressed on myeloid cells 1; targeted mutation 1.1, Christoph Mueller
• MGI ID: MGI:5907248
• Synonyms: Trem1^flox, TREM-1^{tm1821_33.1Arte}
• Gene: Trem1 Location: Chr17:48539796-48553952 bp, + strand Genetic Position: Chr17, 23.99 cM
• Alliance: Trem1^tm1.1Cmuel page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242966
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An F3-flanked puromycin resistance cassette with a 3' loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 2. Flp-mediated recombination removed both selection cassettes and left exon 2 floxed. (J:242966)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trem1 Mutation: 24 strains or lines available

References

• Original: J:242966 Weber B, et al., TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance. PLoS Pathog. 2014 Jan;10(1):e1003900
• All: 1 reference(s)