Acly^tm1.1Welk
Targeted Allele Detail

Summary

• Symbol: Acly^tm1.1Welk
• Name: ATP citrate lyase; targeted mutation 1.1,Kathryn Wellen
• MGI ID: MGI:5907141
• Synonyms: Acly^f
• Gene: Acly Location: Chr11:100367179-100418826 bp, - strand Genetic Position: Chr11, 63.47 cM
• Alliance: Acly^tm1.1Welk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240494
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A KOMP (Acly^{tm184180a(L1L2_Bact_P)}) targeting vector containing a FRT-lacZ-loxP-neo-FRT-loxP cassette was introduced to intron 8, and a loxP site was placed in intron 9 via homologous recombination. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 9 floxed. (J:240494)

Expression

In Mice Carrying this Mutation:

49 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Acly Mutation: 65 strains or lines available

References

• Original: J:240494 Zhao S, et al., ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch. Cell Rep. 2016 Oct 18;17(4):1037-1052
• All: 11 reference(s)