Sik2^tm1.1Mfor
Targeted Allele Detail

Summary

• Symbol: Sik2^tm1.1Mfor
• Name: salt inducible kinase 2; targeted mutation 1.1, Marc Foretz
• MGI ID: MGI:5905012
• Synonyms: SIK2^lox
• Gene: Sik2 Location: Chr9:50804101-50920373 bp, - strand Genetic Position: Chr9, 27.75 cM
• Alliance: Sik2^tm1.1Mfor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242343
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An frt site flanked hygromycin resistance gene cassette was inserted in intron 4. Exon 5 was flanked by loxP sites. Exon 5 codes for part of the active catalytic domain including the Thr175 phosphorylation site within the activation loop. The hygro cassette was removed through subsequent FLP-mediated recombination, leaving a conditional-ready allele with a floxed exon 5. (J:242343)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sik2 Mutation: 46 strains or lines available

References

• Original: J:242343 Patel K, et al., The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver. Nat Commun. 2014 Aug 04;5:4535
• All: 6 reference(s)