About   Help   FAQ
Tg(Myh6-CACNA1C)M1Aschw
Transgene Detail
Nomenclature
Symbol: Tg(Myh6-CACNA1C)M1Aschw
Name: transgene insertion M1, Arnold Schwartz
MGI ID: MGI:5904804
Transgene: Tg(Myh6-CACNA1C)M1Aschw  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-CACNA1C)M1Aschw expresses 1 gene
 
Mutation detailsThe full-length human L-type voltage-dependent calcium channel alpha 1C subunit coding sequence is under the control of the mouse alpha-myosin heavy chain promoter. Five founder lines were established, M1-M5. This line carries 8 copies of the transgene. Western blot analysis confirmed protein expression. (J:129494)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:129494 Muth JN, et al., Cardiac-specific overexpression of the alpha(1) subunit of the L-type voltage-dependent Ca(2+) channel in transgenic mice. Loss of isoproterenol-induced contraction. J Biol Chem. 1999 Jul 30;274(31):21503-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/26/2019
MGI 6.14
The Jackson Laboratory