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Wnt10atm1.1Smr
Targeted Allele Detail
Nomenclature
Symbol: Wnt10atm1.1Smr
Name: wingless-type MMTV integration site family, member 10A; targeted mutation 1.1, Sarah E Millar
MGI ID: MGI:5904667
Synonyms: Wnt10aKO
Gene: Wnt10a  Location: Chr1:74792019-74804176 bp, + strand  Genetic Position: Chr1, 38.54 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:242196
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsLoxP sites were inserted flanking exons 3 and 4, which encode 20 of the 24 conserved, functionally required cysteine residues. Mice carrying this allele were crossed with CMV-Cre mice to delete the loxP-flanked region. (J:242196)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wnt10a Mutation:  13 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: WNT10A mutation
References
Original:  J:242196 Xu M, et al., WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nat Commun. 2017 Jun 07;8:15397
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory