Trpc7^tm1.1Clph
Targeted Allele Detail

Summary

• Symbol: Trpc7^tm1.1Clph
• Name: transient receptor potential cation channel, subfamily C, member 7; targeted mutation 1.1, David E Clapham
• MGI ID: MGI:5904512
• Gene: Trpc7 Location: Chr13:56920911-57043778 bp, - strand Genetic Position: Chr13, 30.27 cM, cytoband B2
• Alliance: Trpc7^tm1.1Clph page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:281818
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was introduced 5' of exon 1 and a FRT-flanked PGK-neomycin cassette and loxP site were placed in intron 1 via homologous recombination. The neo cassette and exon 1 were deleted by transiently transfection of an expression vector of Cre recombinase in the ES cells. (J:281818)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trpc7 Mutation: 39 strains or lines available

References

• Original: J:281818 Xue T, et al., Melanopsin signalling in mammalian iris and retina. Nature. 2011 Nov 2;479(7371):67-73
• All: 2 reference(s)