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Ttc9tm1Vcl
Targeted Allele Detail
Nomenclature
Symbol: Ttc9tm1Vcl
Name: tetratricopeptide repeat domain 9; targeted mutation 1, Valerie Lin
MGI ID: MGI:5904133
Synonyms: Ttc9a-
Gene: Ttc9  Location: Chr12:81631249-81667557 bp, + strand  Genetic Position: Chr12, 37.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:241703
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 1, encoding 70% of the protein, was replaced by a loxP-flanked neomycin resistance cassette. Western blot and immunoblot analysis of brain, mammary gland, lung and uterus confirmed that no protein was expressed in mutant mice. (J:241703)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ttc9 Mutation:  0 strains or lines available
References
Original:  J:241703 Shrestha S, et al., Tetratricopeptide repeat domain 9A negatively regulates estrogen receptor alpha activity. Int J Biol Sci. 2015;11(4):434-47
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory