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Tg(TcraS106-1,TcrbS106-1)TS1SWAjca
Transgene Detail
Nomenclature
Symbol: Tg(TcraS106-1,TcrbS106-1)TS1SWAjca
Name: transgene insertion TS1SW, Andrew J Caton
MGI ID: MGI:5903429
Synonyms: TS1(SW)
Transgene: Tg(TcraS106-1,TcrbS106-1)TS1SWAjca  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x BALB/c
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe transgenic construct expresses a T cell receptor raised against hemagglutinin (HA) from influenza virus A/SW/33(SW), which contains an analog of the S1 determinant that differs from S1 by 2 substitutions, R to K at residue 113 and E to T at residue 120, isolated from hybridoma S106-1. This receptor is encoded by TCR Valpha8.3 and Vbeta10, and has a much lower affinity for the original S1 determinant than does Tg(Tcra/Tcrb)1Vbo . (J:133154)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:133154 Jordan MS, et al., Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol. 2001 Apr;2(4):301-6
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory