Rbm17^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Rbm17^{tm1c(EUCOMM)Hmgu}
• Name: RNA binding motif protein 17; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:5903132
• Synonyms: Rbm17^f
• Gene: Rbm17 Location: Chr2:11590250-11608061 bp, - strand Genetic Position: Chr2, 8.85 cM
• Alliance: Rbm17^{tm1c(EUCOMM)Hmgu} page
• IMPC: Rbm17 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239305
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The L1L2_gt0 cassette was inserted at position 11597239 of Chromosome 2 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site inserted into intron 3. An additional loxP site is inserted into intron 4. Flp-mediated recombination removed the FRT-flanked LacZneo cassette leaving exon 4 floxed. (J:239305)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rbm17 Mutation: 32 strains or lines available

References

• Original: J:239305 Tan Q, et al., Extensive cryptic splicing upon loss of RBM17 and TDP43 in neurodegeneration models. Hum Mol Genet. 2016 Dec 1;25(23):5083-5093
• All: 2 reference(s)