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Targeted Allele Detail
Symbol: Braftm1Tumg
Name: Braf transforming gene; targeted mutation 1, Yoko Aoki
MGI ID: MGI:5902220
Synonyms: BrafQ241R Neo
Gene: Braf  Location: Chr6:39603237-39725463 bp, - strand  Genetic Position: Chr6, 18.43 cM
Germline Transmission:  Earliest citation of germline transmission: J:216228
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Allele Type:    Targeted (Conditional ready)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsA PGK-Neo-STOP cassette flanked by loxP sites was inserted in intron 6 and a glutamine to arginine substitution at amino acid 241 (Q241R) was inserted into exon 7 via homologous recombination. The mutant transcript is expressed only after cre-mediated recombination. (J:216228)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Braf Mutation:  38 strains or lines available
Original:  J:216228 Inoue S, et al., New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome. Hum Mol Genet. 2014 Dec 15;23(24):6553-66
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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