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Chemically induced Allele Detail
Symbol: Ube2ohem9
Name: ubiquitin-conjugating enzyme E2O; haematopoietic 9
MGI ID: MGI:5902131
Synonyms: hem9, Ube2oE1121X
Gene: Ube2o  Location: Chr11:116537740-116581447 bp, - strand  Genetic Position: Chr11, 81.42 cM
Strain of Origin:  C57BL/6J
Allele Type:    Chemically induced (ENU) (Null/knockout)
Mutation:    Nucleotide substitutions
Mutation detailsThis allele was identified in a screen for a metabolic and haematopoietic phenotype described as hypochromic, microcytic anemia associated with erythrocytosis using ENU-treated C57BL/6J males (G0). Sequencing identified a G to T substitution, resulting in a E1121X (changing glutamic acid to a termination codon) mutation in the Ube2o gene. The mutation causes truncation of the C-terminal 168 amino acids and is a loss-of-function mutation. No gene product (protein) is detected by western blot analysis of blood. (J:243727)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ube2o Mutation:  35 strains or lines available
Original:  J:243727 Nguyen AT, et al., UBE2O remodels the proteome during terminal erythroid differentiation. Science. 2017 Aug 04;357(6350)
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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