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Trem2tm1c(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Trem2tm1c(EUCOMM)Wtsi
Name: triggering receptor expressed on myeloid cells 2; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:5897643
Gene: Trem2  Location: Chr17:48346401-48352276 bp, + strand  Genetic Position: Chr17, 23.99 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  JM8A1.N3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 48236393 of Chromosome 17 upstream of exon 2 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted upstream of exon 4 at position 48237757. A "conditional ready" (floxed) allele is created by flp recombinase expression in mice carrying this allele. (J:173534)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Trem2 Mutation:  29 strains or lines available
References
Original:  J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/21/2020
MGI 6.14
The Jackson Laboratory