Rdh10^tm1.1Eper
Targeted Allele Detail

Summary

• Symbol: Rdh10^tm1.1Eper
• Name: retinol dehydrogenase 10 (all-trans); targeted mutation 1.1, Edgar M Pera
• MGI ID: MGI:5897440
• Gene: Rdh10 Location: Chr1:16176106-16202774 bp, + strand Genetic Position: Chr1, 4.94 cM
• Alliance: Rdh10^tm1.1Eper page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240765
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 2 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 4. This creates a conditional-ready allele with exons 3 and 4 floxed. Through cre-mediated recombination these two exons, coding for the active site of the enzyme, were deleted, also causing a frameshift in the downstream exons. This creates a null allele. (J:240765)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rdh10 Mutation: 20 strains or lines available

References

• Original: J:240765 Arregi I, et al., Retinol Dehydrogenase-10 Regulates Pancreas Organogenesis and Endocrine Cell Differentiation via Paracrine Retinoic Acid Signaling. Endocrinology. 2016 Dec;157(12):4615-4631
• All: 1 reference(s)