Cyld^tm1.1Attg
Targeted Allele Detail

Summary

• Symbol: Cyld^tm1.1Attg
• Name: CYLD lysine 63 deubiquitinase; targeted mutation 1.1, Adrian T Ting
• MGI ID: MGI:5897343
• Synonyms: Cyld^flox
• Gene: Cyld Location: Chr8:89423675-89478573 bp, + strand Genetic Position: Chr8, 43.51 cM
• Alliance: Cyld^tm1.1Attg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238243
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 8 and 9 were floxed. The final allele lacks the loxP- and FRT-flanked neomycin resistance selection cassette. (J:238243)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyld Mutation: 45 strains or lines available

References

• Original: J:238243 Legarda D, et al., CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN. Cell Rep. 2016 Jun 14;15(11):2449-61
• All: 3 reference(s)