Rr167^tm1.1Masar
Targeted Allele Detail

Summary

• Symbol: Rr167^tm1.1Masar
• Name: regulatory region 167; targeted mutation 1.1, Masafumi Arima
• MGI ID: MGI:5897323
• Synonyms: hcIE-KO, Il4^tm1.1Masar
• Gene: Rr167 Location: Chr11:53508097-53508316 bp Genetic Position: Chr11, Syntenic
• Alliance: Rr167^tm1.1Masar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240744
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph, Modified regulatory region)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 445 bp deletion in intron 2 of Il4 was engineered by replacing the sequence with a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent cre-mediated recombination, leaving an allele lacking the 220 bp highly conserved intron enhancer (hcIE). Expression from this allele is greatly reduced compared to wild-type. (J:240744)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr167 Mutation: 0 strains or lines available

References

• Original: J:240744 Ogasawara T, et al., Development of chronic allergic responses by dampening Bcl6-mediated suppressor activity in memory T helper 2 cells. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E741-E750
• All: 1 reference(s)