Odc1^tm2.1Jlc
Targeted Allele Detail

Summary

• Symbol: Odc1^tm2.1Jlc
• Name: ornithine decarboxylase, structural 1; targeted mutation 2.1, John L Cleveland
• MGI ID: MGI:5897310
• Synonyms: Odc^fl
• Gene: Odc1 Location: Chr12:17594906-17601503 bp, + strand Genetic Position: Chr12, 8.11 cM
• Alliance: Odc1^tm2.1Jlc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240745
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT site flanked neomycin resistance gene cassette and a loxP site were inserted into intron 1 and a second loxP site into intron 3. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exons 2 and 3 floxed. Exon 3 contains the translation start site codon. (J:240745)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Odc1 Mutation: 34 strains or lines available

References

• Original: J:240745 Hardbower DM, et al., Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E751-E760
• All: 6 reference(s)